Pulmonary Medicine Research

J. Michael Collaco, M.D., M.S., M.P.H., M.B.A., Ph.D.

J. Michael Collaco 是一名临床科学家,他的研究重点是慢性儿科呼吸系统疾病的危险因素的流行病学, particularly cystic fibrosis and bronchopulmonary dysplasia. 他在囊性纤维化方面的工作主要集中在遗传流行病学方面,通过基因-环境相互作用研究致病基因(CFTR)和修饰基因. Dr. Collaco maintains one of the largest registries of outpatients with bronchopulmonary dysplasia in the U.S. Clinically, his practice includes general pulmonary and bronchopulmonary dysplasia.

Dr. Collaco participates in a multidisciplinary aerodigestive clinic, 他是约翰霍普金斯大学遗传性出血性毛细血管扩张卓越中心的儿科肺病顾问. He also serves as a consultant for medically complex children at two subacute facilities in Baltimore. Dr. Collaco为对儿科呼吸疾病流行病学感兴趣的学员提供研究指导, and formal education for the pediatric pulmonary fellowship as the fellowship director. He also serves as faculty for the pediatric palliative care fellowship.

Maureen A. Lefton-Greif, Ph.D., CCC-SLP, BCS-S

Maureen A. Lefton-Greif领导的临床实践和研究侧重于喂养/吞咽发展及其疾病的评估和管理. 她的具体研究兴趣是儿童和成人的吞咽障碍(吞咽困难),诊断为复杂的空气消化系统疾病和儿科起源的罕见疾病. Dr. Lefton-Greif参与了多学科临床和研究小组,研究共济失调毛细血管扩张(A-T)的自然史。, 也是美国国立卫生研究院支持的R21基金的联合研究员,该基金旨在开发临床试验准备的功能规模. Her RO1-funded research led to the development of a standardized, reliable and valid scale for the videofluoroscopic assessment of swallowing function of bottle-fed children. As an extension of this work, Dr. Lefton-Greif是RO1资助的研究人员之一,研究婴儿和儿童在透视吞咽研究中的辐射暴露. 她正在研究非放射吞咽测量在神经肌肉疾病患者中的应用, 并制定了第一个结果衡量标准,以评估儿童喂养和吞咽问题对其照顾者的影响, which has been translated into Turkish and Brazilian Portuguese. 她是美国语言听力协会的会员,也是吞咽和吞咽障碍认证专家委员会的创始成员.

Eric McCollum, M.D.

Eric McCollum is director of the Johns Hopkins Global Pediatric Respiratory Sciences Program. His research focuses on optimizing respiratory care for children in low-resourced settings. Dr. McCollum在非洲南部和南亚的低收入和中等收入国家有十多年的临床和研究经验. Dr. 麦科勒姆作为临床医生和美国国立卫生研究院福格蒂国际临床研究员在马拉维生活了五年, 并作为NIH K01国际研究科学家发展奖的首席研究员在孟加拉国生活了两年, through the Fogarty International Center, examining the role of pulse oximetry in Bangladeshi children with clinical pneumonia.

Since 2018, he has been based full-time in the southern African country of Lesotho. Dr. McCollum has successfully designed, led or co-led several multisite studies in developing countries throughout Africa and Asia. He advises multiple international foundations and organizations, including the World Health Organization (WHO), on a variety of child respiratory health areas. 他是世卫组织儿童疾病综合管理指南技术工作组的成员, a member of the WHO Technical Support Network for pneumococcal conjugate vaccine impact studies, 并作为修订世卫组织儿童胸片指南的全球专家工作组成员. Dr. 麦科勒姆是约翰霍普金斯大学彭博公共卫生学院国际卫生系的联合教员.

M. Cecilia Melendres, M.D.

M. Cecilia Melendres is board-certified in sleep medicine and pediatric pulmonology. Her clinical work focuses on pediatric sleep-disordered breathing. 她对手术治疗后持续性阻塞性睡眠呼吸暂停的高风险儿童特别感兴趣, including those with Down syndrome, obesity and neuromuscular disorders. Dr. Melendres is involved in a multicenter, retrospective and prospective research study on early onset narcolepsy, which is looking into the recent increase in cases of narcolepsy, its seasonal variation and the role of infection.

Peter J. Mogayzel, Jr., M.D., Ph.D., M.B.A.

Peter J. Mogayzel, Jr., is director of the Cystic Fibrosis Center. His clinical work, teaching and research focuses on the treatment of children with cystic fibrosis. Dr. Mogayzel’s research interests include understanding the regulatory properties of the CFTR gene, mucociliary clearance and development of new therapeutics for cystic fibrosis. He is co-director of the Cystic Fibrosis Therapeutics Development Center at Johns Hopkins, and he served as the principal investigator for both investigator-initiated and multicenter clinical trials. Dr. Mogayzel曾担任囊性纤维化基金会治疗发展网络协议审查委员会主席, and he currently serves on the board of trustees for the foundation.

Shruti M. Paranjape, M.D.

Shruti Paranjape is a clinician-researcher whose expertise incorporates independent and collaborative efforts to study sleep, respiratory mechanics, energy expenditure and nutrition in children and young adults with cystic fibrosis (CF). She is a co-investigator for an NIH-supported multicenter CF liver disease study, serving as the only pediatric pulmonologist on the study’s steering committee, and for ongoing clinical trials for children with spinal muscular atrophy.

Dr. Paranjape领导了由儿科和CF基金会支持的质量改进计划. 她于2013年当选为美国儿科学会(AAP)儿科肺病学和睡眠医学分会执行委员会成员. Her work with the section includes quality improvement initiatives, editorial board membership, 并制定临床实践和技术指南,以规范和提高小儿呼吸系统疾病的临床管理. Dr. Paranjape is an AAP fellow, member of the Society for Pediatric Research, and serves on the regional and national medical advisory panels for the Make-A-Wish Foundation.

S. Christina Sadreameli, M.D.

S. Christina Sadreameli 儿科肺科医生是否有镰状细胞病肺部并发症的临床和研究重点. 她是镰状细胞病和环境对肺功能影响(SELF)试验的首席研究员. This two-site, prospective, observational cohort examines the relationship between indoor environmental exposures, including tobacco smoke and allergens, and pulmonary complications, including asthma, lower airway obstruction and acute chest syndrome, in pediatric patients with sickle cell disease. She is also interested in asthma and the impact of secondhand smoke exposure in pediatric chronic disease.

Laura Sterni, M.D.

Laura Sterni 是一名获得委员会认证的儿科肺病和睡眠医学专家,并专注于儿童呼吸控制障碍和睡眠呼吸障碍的临床和研究. Dr. Sterni is director of the Johns Hopkins Pediatric Sleep Center, 一个多专业的儿童睡眠中心,为马里兰州及其他地区的儿童提供最先进的护理. 该中心在评估和管理患有睡眠呼吸障碍的医学复杂儿童方面的能力得到了全国的认可. Dr. Sterni也是管理需要家用呼吸机支持的慢性呼吸衰竭儿童的专家. 她是最近出版的美国胸科学会临床实践指南的第一作者,该指南涉及这些复杂患者的护理, and has edited a book on the topic titled Caring for the Ventilator Dependent Child: A Clinical Guide.

Lori Vanscoy, M.D.

Lori Vanscoy leads research focused on the application of precision medicine in cystic fibrosis (CF) care. 她正在与工程同事合作,使用约翰霍普金斯大学开发的汗液传感器来测量CF患儿运动时汗液中的氯化物浓度, 长期目标是将该设备纳入家庭监控计划,以监测调节剂药物的反应. A second aim of Dr. 范斯科伊的研究是利用现有的CFTR遗传信息和电子病历中的颗粒数据创建CF“指纹”, which will be extracted and categorized using machine learning techniques, including natural language processing. This fingerprint, which is designed to capture the complexity and heterogeneity of the CF phenotype, will inform individualized treatment decisions and provide a robust phenotype for future clinical research.

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